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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN11
All Species:
27.27
Human Site:
S503
Identified Species:
60
UniProt:
Q06124
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06124
NP_002825.3
597
68436
S503
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
Chimpanzee
Pan troglodytes
XP_001164543
512
58884
S418
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
A495
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
Dog
Lupus familis
XP_534686
571
65327
I478
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
Cat
Felis silvestris
Mouse
Mus musculus
P35235
597
68442
S503
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
Rat
Rattus norvegicus
P41499
597
68440
S503
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519242
359
41028
Q266
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Chicken
Gallus gallus
Q90687
593
67964
S499
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
Frog
Xenopus laevis
NP_001084076
595
68232
S499
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
S623
R
T
I
Q
M
V
R
S
Q
R
S
G
L
V
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
V440
T
E
A
Q
Y
K
F
V
Y
R
A
V
Q
H
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.7
54
95.1
N.A.
99.5
98.9
N.A.
59.2
97.6
93.4
N.A.
N.A.
38.5
N.A.
N.A.
51.9
Protein Similarity:
100
85.7
70
95.1
N.A.
99.8
99.5
N.A.
60.1
98.4
95.8
N.A.
N.A.
51.3
N.A.
N.A.
65.8
P-Site Identity:
100
100
93.3
13.3
N.A.
100
100
N.A.
6.6
100
100
N.A.
N.A.
86.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
26.6
100
100
N.A.
N.A.
100
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
10
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
10
% D
% Glu:
0
10
0
10
0
0
0
0
10
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
0
0
0
0
0
0
73
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
0
10
73
10
0
10
0
10
10
0
0
0
0
0
0
% I
% Lys:
64
0
10
0
0
10
0
0
0
0
10
10
10
0
0
% K
% Leu:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% L
% Met:
0
0
0
0
73
0
0
0
0
0
0
0
64
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
10
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
82
0
10
0
10
73
0
0
0
10
0
73
% Q
% Arg:
10
10
0
0
0
0
82
0
0
91
0
0
0
0
10
% R
% Ser:
10
0
0
0
0
0
0
64
0
0
73
0
0
0
0
% S
% Thr:
10
73
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
10
0
0
0
0
73
0
10
0
0
0
10
0
82
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
0
10
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _